Molecular Genetic Studies of Sporadic and MEN1-Associated Endocrine Pancreatic Tumors
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چکیده
منابع مشابه
Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance.
Proliferative changes in the neuroendocrine cells that precede neoplasia are of interest for the understanding of tumorigenesis and the early recognition of neuroendocrine tumors. This review focuses on precursor lesions of duodenal and pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) and also discusses 2 new disease entities of pancreatic microadenomatosis. The ga...
متن کامل[Genetic profile of gastroenteropancreatic neuroendocrine tumors].
Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms but their incidence has significantly increased in the last 30 years. These tumors are usually sporadic but can also occur as part of certain endocrine tumor susceptibility syndromes such as multiple endocrine neoplasia type1 (MEN1) and von Hippel Lindau disease. The genetic abnormalities associated with the development ...
متن کاملLocalization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.
The gene for multiple endocrine neoplasia type 1 (MEN1), an inherited predisposition to neuroendocrine neoplasm of the parathyroid glands, the pancreatic islet parenchyma, and the anterior pituitary gland, was recently mapped to chromosome 11q13 based on genetic linkage in families. We now show that the pathogenesis of MEN1-associated parathyroid lesions involves unmasking of a recessive mutati...
متن کاملMutation of the MENIN gene in sporadic pancreatic endocrine tumors.
Pancreatic endocrine tumors occur both sporadically and as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome. MEN1 is an autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. The MEN1 gene called MENIN maps to chromosome 11q13 and is thought to function as a tumor suppressor gene. We previously demonstrated loss o...
متن کاملSystematic comparison of sporadic and syndromic pancreatic islet cell tumors.
Pancreatic islet cell tumors (ICTs) occur as sporadic neoplasias or as a manifestation of multiple endocrine neoplasia type 1 (MEN1) and von Hippel-Lindau disease (VHL). Molecular classification of ICTs is mandatory for timely diagnosis and surveillance. Systematic comparison of VHL-ICTs and sporadic ICTs has been lacking. Our registry-based approaches used the German NET-Registry with 259 pati...
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تاریخ انتشار 2007